This study was an open, randomized, double-blind, placebo-controlled, parallel-design, multicenter, phase 2 study that evaluated the efficacy of aciclovir (Acarbavir, 500 mg orally, three times per day) vs. valaciclovir (Acarbavir, 500 mg orally, twice daily) in patients with recurrent genital herpes (shingles), recurrent genital herpes simplex, recurrent genital herpes labialis, recurrent genital herpes infections, recurrent herpes labialis, and recurrent genital herpes. A total of 56 patients with recurrent genital herpes were randomized to receive aciclovir (n = 35), valaciclovir (n = 30), or placebo. The primary end point was a change from baseline in the herpes labialis score. Secondary end points included laboratory parameters, clinical cure rates, and adverse events. Overall, 30 patients (mean age, 66.1 years) and 40 patients (mean age, 58.7 years) completed the study. The mean change from baseline in the herpes labialis score (n = 22) was -0.02 (95% confidence interval -0.15 to -0.05) for aciclovir and -0.03 (0.17 to -0.05) for valaciclovir. The mean change from baseline in the clinical cure rates was -0.09 (0.17 to 0.17) for aciclovir and -0.06 (0.17 to 0.08) for valaciclovir. The mean change in the laboratory parameters was -0.13 (0.19 to -0.20) for aciclovir and -0.12 (0.21 to 0.18) for valaciclovir. The mean change from baseline in adverse events was -0.19 (0.24 to 0.28) for aciclovir and -0.14 (0.23 to 0.27) for valaciclovir. The most common adverse events were headache (n = 15), nausea (n = 10), vomiting (n = 2), abdominal pain (n = 1), and diarrhea (n = 1). The most common complications in patients receiving aciclovir were headache (n = 16), nausea (n = 9), and vomiting (n = 1). There were no statistically significant differences in the frequency of adverse events between aciclovir-treated and valaciclovir-treated patients.
In the aciclovir-treated patients, the mean change from baseline from baseline was -0.09 (0.16 to -0.19) for aciclovir and -0.06 (0.17 to -0.08) for valaciclovir. The mean change from baseline in the clinical cure rates was -0.12 (0.22 to -0.22) for aciclovir and -0.08 (0.19 to -0.13) for valaciclovir. The mean change from baseline in the laboratory parameters was -0.15 (0.24 to 0.33) for aciclovir and -0.14 (0.25 to 0.27) for valaciclovir. The most common adverse events were headache (n = 15), nausea (n = 9), and vomiting (n = 1).The primary end point was the change from baseline in the herpes labialis score, which was -0.03 (0.16 to -0.06) for aciclovir and -0.04 (0.16 to -0.09) for valaciclovir. Secondary end points included laboratory changes, clinical cure rates, and adverse events. The most common changes from baseline in the laboratory changes were: decrease in body weight (n = 10), anemia (n = 8), and decreased hemoglobin (n = 8).The data on adverse events were analyzed by treatment with Acarbavir or Acarbavir and then by the change from baseline in the patient's laboratory values. The most common side effects of aciclovir were headache (n = 15), nausea (n = 10), and vomiting (n = 1).
Table 1Patient characteristics and laboratory changes of aciclovir (n = 35) and valaciclovir (n = 30) for shingles.
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Aciclovir belongs to the group of medicines called antivirals. It is used to treat viral infections caused by herpes simplex, genital infections, including genital herpes, as well as a number of infections caused by the human papillose and recurrent infections of the family H. pylori. Aciclovir prevents the multiplication of virus particles by interfering with the herpes virus’s ability to trigger the virus to replicate. This ultimately prevents the infection from occurring. In most cases, genital herpes is caused by the herpes simplex virus type 1 (HSV-1), whilst a high level of HSV-2 can cause HSV-3 (the common cold). The risk of getting genital herpes is increased if there is a previous history of HSV-1 infection with an H. pylori infection. Aciclovir also helps to reduce the risk of getting cytomegalovirus (CMV) infection, which is a common cause of cancer. CMV is a chronic immune-deficiency disease associated with advanced blood and organs, particularly bone marrow, heart, and kidney. Aciclovir reduces the production of a virus by the immune system which causes cancer.
Warnings and Precautions
Do not take Aciclovir if:
Some of the precautions you should keep in mind while taking Aciclovir,
If you have any of the above-listed risk factors then you should also inform your doctor about any other health problems you have had prior to starting treatment.
It is best to consult a doctor or pharmacist before starting treatment if you have any of the following conditions:
If you are pregnant or trying to get pregnant or are breast-feeding then the risk of getting pregnant from Aciclovir during pregnancy is very small. So please talk to your doctor if you are breastfeeding or are pregnant.
You can take Aciclovir with or without food, but please ensure you take it with a full glass of water.
Do not stop taking Aciclovir suddenly, as the infection can return. If you do stop taking Aciclovir then the infection will continue and will be harder to treat. You should also inform your doctor about any side effects you might experience or any other medical conditions you may experience.
If you have any questions regarding the use of Aciclovir then please talk to your doctor or pharmacist.
Before taking Aciclovir:
Aciclovir is not recommended for use in children. Therefore, you should consult your doctor before taking Aciclovir.
The full list of precautions and warnings is here.
If you havesix or more recurrent outbreaksof genital herpesa yearor if yoursymptoms are very severeand causing youdistress, you can take aciclovir every day on a long-term basis. This issuppressive treatmentand it aims to stop outbreaks happening at all.
How often do I take suppressive treatment? You take one aciclovir 400mg tablet twice a day.
Thetreatment is continued for six to 12 months. Then you have a break from medication to re-assess recurrence frequency. Suppressive treatment may be restarted if you have further severe outbreaks. Suppressive treatment can reduce the risk of passing HSV on to your partner but it cannot prevent it altogether and so you should always wear a female or male condom during any sexual activity. If you are experiencing recurrent outbreaks of genital herpes you should also consider being tested for HIV as it may be a sign of a weakened immune system due to HIV.Caution: It’s important to maintain adequate hydration while taking either of the treatments for genital herpes.
What is suppressive treatment for genital herpes? Suppressive treatment forsexual herpesorherpes simplex virus (HSV) 1 or 2The dosage of theyou take is determined by your risk of passingYou can take either aciclovir 400mg tablet or valaciclovir 500mg tablet once daily on a long-term basis. Aciclovir is an antiviral medication that aims to be very help for sexual herpes outbreaks because it targets viruses that are usually responsible for the outbreaks. This means that you can help your situation through better control over your outbreaks so that they don’t happen again. suppressive treatment helps by preventing outbreaks from happening so that they don’t happen to you. You should re-assure yourself that you’re getting the treatment you need because it could mean that you’re passing genital herpes or being exposed to another virus.
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Aciclovir is a antiviral medication that targets viruses that are usually responsible for the outbreaks. this means that you can helpby re-assure yourself that you’re getting the treatment you need............................................................................................................................................................................................................................................................................
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